What Jobs are available for Scientific Research in the United States?

St Jude Children’s Research Hospital is a private, not-for-profit institute that is internationally recognized for its commitment to providing state of the art clinical services, while performing innovative scientific and patient-directed research. St. Jude is the first and only pediatric cancer center to be designated as a Comprehensive Cancer Center by the National Cancer Institute.

We are looking for a talented and enthusiastic Scientific Director for the Immune Monitoring Core (IMC) of the in the Department of Bone Marrow Transplantation & Cellular Therapy (BMTCT). The IMC performs immune monitoring studies for clinical transplant, cell therapy, and gene therapy studies conducted in the BMTCT department. In addition, it serves as resource for research staff and investigators within the translational research laboratories of the BMTCT department. The core works closely together with BMTCT’s flow cytometry and cell sorting core and interacts with the Center for Translational Immunology and Immunotherapy (CeTI2) on a regular basis. The Scientific Director will join a highly cooperative research team that strives to build and maintain a culture of respect and collaboration. Likewise, the BMTCT department cares deeply about the success and professional growth of its research staff. Applicants with experience in molecular biology, functional evaluation of human immune cells, and research team management are strongly encouraged to apply.

Job Responsibilities:

• Leads and directs the operation of the IMC which consists of three members and currently conducts the following tasks/assays: PBMC isolation, qPCR and dPCR assays, vector integration site analysis, TREC analysis, TCR Vbeta spectratyping, multiplex analysis (Luminex, Olink), and ELISPOT assays.
• Oversees the IMC’s Standard Operating Procedures (SOPs) and databases.
• Reviews assay results, performs data analysis, prepares reports, and communicates results to investigators and research teams.
• Proposes innovative and differentiating technologies/assays, oversees their adoption and implementation (including SOP development).
• Drives and manages scope, schedule, and resources of the core to ensure that assays are performed in line with the needs of investigators and research teams.
• Prepares presentations and supports manuscript, grant submissions, FDA responses, and IND submissions.
• Collaborates with other cores and research teams (e.g., BMTCT’s flow cytometry and cell sorting core, CeTI2, Center of Excellence for Pediatric Immuno-Oncology).
• Actively guides budget development, implementation of strategic initiatives and ongoing fiscal review of the core.
• With departmental leadership, actively drives processes for team management, including hiring, goal setting, performance, training and development, and engagement.

Minimum Education and/or Training:

• Bachelor’s degree in relevant scientific discipline is required.

Minimum Experience:

• 10+ years of experience in relevant technical field (industry or academia) is required.
• 8+ years of experience in relevant technical field is required with a Master’s degree.
• 5+ years of experience in relevant technical field is required with a PHD.
• Significant experience in a research functional area with experience managing mid-large teams in a leadership capacity with focus on both achievement of objectives as well as critical skill-building preferred.
• Experience having led large-scale projects/processes through to implementation preferred.
• Experience with operational mgmt., budget planning, & stakeholder and resource management preferred.
• Prior experience in building external connections with peers, emerging technology communities, and expert networks preferred.
• Experience driving research objectives across area through collaboration with internal and external stakeholders preferred.
• Proven performance in earlier role/comparable role.

Compensation: In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into

Location: San Diego, CA, 100% on-site, lab-based role.

1. Bachelor's degree in Biology (no PhD candidates)
2. 2+ years of wet lab experience (not including lab classes): experience in mammalian cell culture is required.
3. Basic molecular biology skills (PCR especially; familiarity with library prep preferred)
4. Proficient in laboratory math (dilutions, cell count-based plating)

The Oncology Discovery team at the Oncogenesis Thematic Research Center is seeking a Research Associate to support our drug discovery and characterization efforts.

An early-career level position. Familiarity with core industry and lab practices and standards. The qualified candidate will leverage various CRISPR/Cas9 technologies to enable genetic/multiplexed cell line screens to support early and late stage drug mechanism of action studies. They will assist senior team members in performing the totality of the screening process, including cell line engineering, cell treatment experiments, NGS library preparation, and target validation. Common skills and techniques used will include mammalian cell culture, lentiviral transduction, DNA/protein isolation, PCR, flow cytometry, and western blot.

The successful candidate will demonstrate strong verbal and written communication skills and will be capable of working collaboratively in a multidisciplinary environment. Must demonstrate the ability to multi-task and prioritize time management of daily activities to deliver timely results. Wet lab research experience is required, no PhD candidates.

1. Bachelor's degree in Biology (no PhD candidates)
2. 2+ years of wet lab experience (not including lab classes): experience in mammalian cell culture is required.
3. Basic molecular biology skills (PCR especially; familiarity with library prep preferred)
4. Proficient in laboratory math (dilutions, cell count-based plating)
5. Excellent organizational skills and record-keeping (Excel & Powerpoint)

1. Execute cellular and molecular biology protocols in the laboratory
2. Maintain cancer cell lines and establish new stable lines via lentiviral transduction
3. Validate engineered cell lines by reporter assays and PCR
4. Perform genetic targeting using siRNA, shRNA or CRISPR/Cas9 technology for cell line characterization and screening
5. Conduct routine molecular and cellular experiments including gDNA and RNA isolation, PCR, cloning, western blot analysis, flow cytometry, and microplate cell proliferation assays
6. Identify experimental issues, troubleshoot, and recommend a corrective course of action
7. Design experiments and protocol optimization in collaboration with senior researchers
8. Maintain detailed lab notebooks and record data in electronic notebook in accordance with company policy
9. Communicate results in written and oral presentations

The starting hourly compensation for this assignment is a range from $26.58-$33.75. While the final, individual compensation will be determined by your employer of record (and not Client), factors that will be included in making the final determination may include the characteristics of the assignment, such as demonstrated experience, required skill, and the geographic location where the job is performed. The starting hourly compensation may be subject to change.

Job Title: Associate Research Scientist
Location: San Diego, CA ONSITE (Schedule will vary. CW may be required to work a Saturday, and some days hours will be around 10:00am-6:00pm)

Top Skills:

1. Experience working in a BSL2+ environment.
2. Experience with human biospecimens (Preferred)
3. Excellent organizational skills and attention to detail
4. A B.S. degree in a scientific discipline with >2 years research experience (experience in the biotech or pharmaceutical industry preferred).

Position Summary:
Participate as part of the Oncogenesis PD assay team (CITRE and US) in processing of patient samples, control storage of vials and deliver sample to analysis teams to provide data in different clinical trials.

Key Responsibilities:

1. Support in providing timely PD data during Phase I trials from ONC-TRC to support
2. Accountable for planning, coordinating, and processing of clinical samples within the guidelines set by established clinical trial protocols
3. Responsible for chain of custody documentation for samples, including entry of key data elements into internal databases
4. Collaborate with the clinical sample management team to deliver samples to analysis teams for timely data reporting
5. Identification and escalation of issues to clinical trial points of contact to ensure resolution
6. Organize inventory of patient samples. Enter and update database information for different clinical trials
7. Organize stock of reagents
8. Keep a record of the batches of reagents used with each patient sample

Qualifications & Experience:

1. A B.S. degree in a scientific discipline with >2 years research experience (experience in the biotech or pharmaceutical industry preferred).
2. Excellent organizational skills and attention to detail
3. Experience working in a BSL2+ environment
4. Hands-on experience working with primary cell cultures and immortalized cell lines
5. Knowledge of clinical trials and biomarkers
6. Flexible to adapt to changing work assignments
7. Ability to collaborate with scientists, vendor labs, and other internal team players
8. Good Computer skills (mainly Microsoft Office package and databases)
9. High capacity of teamwork
10. Autonomy

Job Title

Sr. RA/Assoc. Sci, AAV Vector Biology and Molecular Optimization, Gene Delivery Process and Analytical Development

Location: Seattle, WA

Total CWs needed: 3

1. 2+ years of hands-on lab work on biotech industry
2. Experience in process development: Upstream process development and/or mammalian cell culture OR Downstream process development/purification
3. Bachelor's degree in STEM field

The senior research associate/associate scientist will join the Gene Delivery Process and Analytical Development (GDPAD) organization supporting process development, production, and characterization of viral vectors, which are critical to generating groundbreaking cell therapies.

The associate will join the AAV Platform Development team working on vector biology and molecular optimization initiatives intended to drive next-generation viral vector platform development. Specifically, in the pursuit of end-to-end assessment of Client technologies and approaches, the associate will seek to become highly proficient in upstream production and downstream purification of recombinant AAV, while gaining familiarity with AAV analytical methods and their interpretation in the context of AAV attributes and biology. The associate will also have the unique opportunity to be exposed to a wide range of highly Client molecular designs and to work collaboratively with a range of different groups doing different types of rAAV development.

1. Execute and troubleshoot upstream and downstream process development experiments supporting next-generation AAV production
2. Manage the flow of samples and data and perform analyses
3. Assist in the design of experiments and interpretation of data
4. Optimize workflows for assessing new constructs and modes of production
5. Provide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.)
6. Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities
7. Actively participate and support lab maintenance and continuous improvement initiatives
8. Maintain accurate and detailed laboratory notebook and documentation
9. Summarize and present data in group meetings and contribute to group discussions and team strategy
10. Author technical reports and study memos

1. STEM degree with 2+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset
2. Experience with suspension culture of mammalian cells in shake flasks and small stirred tank bioreactors
3. Hands-on experience in process development
4. Independently motivated with ability to work in teams
5. Ability to communicate clearly and concisely through oral presentation and technical writing
6. Ability to leverage literature, internal and external resources to solve problems
7. Desire to identify and advance the cutting edge
8. Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment

1. Degree in biological or chemical engineering, biochemistry, or bio-related field
2. Hands-on experience in downstream purification including chromatography and filtration
3. Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful

Job Description

Actalent is hiring for a Research Associate role in the Round Lake area!

Job Description

Join a dedicated team where your work improves patient outcomes worldwide. As a Research Associate, you will be part of a mission-driven organization that pioneers medical innovations and collaborates cross-functionally to deliver impactful research and development results.

Responsibilities

• Conduct critical chemical and physical analyses on finished product R&D stability samples.
• Support testing of raw materials, initial in-process, and final product samples from manufacturing facilities or other R&D initiatives.
• Perform chemical assays with precise analytical skills and understanding of chemistry principles.
• Complete all testing, including special project/protocol testing, in a timely manner to meet project schedules.
• Maintain data integrity and ensure compliance with company SOPs, FDA cGxP, and QSR regulations.
• Collaborate with other departments to solve problems, increase efficiency, improve quality, and provide product support.
• Use sophisticated laboratory instrumentation such as HPLC, pH meters, UV titrations, and more to collect and record data.
• Follow and comply with SOPs and policies on cGMPs and safety, maintaining a clean and organized lab area.
• Perform equipment maintenance/calibration and troubleshoot instrumentation.
• Maintain laboratory safety requirements.

Essential Skills

• Bachelor's degree in a relevant scientific discipline such as chemistry, pharmaceutical sciences, or biology.
• 6 months or more of experience in a scientific role.
• Experience in a regulated environment with strong technical problem-solving skills.
• Good oral and written communication skills.
• Strong analytical skills and attention to detail.
• Experience with electronic lab notebooks is preferred.
• Experience with pharmaceutical GMP laboratory is desired.

Additional Skills & Qualifications

• Analytical chemistry instrumentation experience with pH, UV titrations, and Particle TOC is preferred.
• Empower software experience is preferred.
• Ability to handle multiple tasks concurrently in a timely fashion.
• Relevant laboratory/technical writing and computer skills.
• Ability to organize and communicate complex information effectively.

Work Environment

This on-site position requires handling various physical activities, including handwriting and computer use for most of the workday, transferring materials, mixing solutions, and performing laboratory tests. Standing for extended periods and lifting up to 10 pounds may be required. The work involves potential exposure to chemicals and drug products, including Penicillin and Cephalosporin. The laboratory environment adheres to strict safety regulations and standards.

The pay range for this position is $25.00 - $30.00/hr.

Eligibility requirements apply to some benefits and may depend on your job
classification and length of employment. Benefits are subject to change and may be
subject to specific elections, plan, or program terms. If eligible, the benefits
available for this temporary role may include the following:

• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending